Can be negated with Black Candle, Bad Gas - Isaac farts, poisoning enemies around him, Bombs are key - Switches number of bombs and keys, Explosive Diarrhea - Spawns five live troll bombs behind Isaac, one per second, Full Health - Restores all your empty red heart containers, Health Down - -1 HP. This will deviate you from the alt path if you are currently on it, Since this item resets your stats, this item can remove Broken Hearts, UNLOCK: Unlock this item by defeating Greedier Mode as Jacob & Esau, Item Pool: Angel Room, Greed Mode Angel Room, Upon use, allows you to consume 1 key and fire it at an enemy, piercing enemies and dealing significant damage, The damage done by the key projectile pierces through enemies and scales with your damage upgrades (x5 damage + 30), Keys fired by this item can open locked doors/chests, secret rooms and destroy objects in the room, such as rocks, Cannot be used if you don't have any keys, Enemies killed by Sharp Key have a ~10% chance to spawn random items that appear in a chests. Item Pool Blood clots can be life-threatening depending on their location and severity. 5.100.531 Every time you use Wavy Cap, it gives +0.75 Tears Up and -0.03 Speed Down, Also when used, this item will distort the screen and sound slightly, stacking every time you use it, All of these effects stack for the rest of the floor, meaning if used too many times the screen will be distorted so much it becomes unplayable, Each room you clear removes one use worth of effect - reducing the screen distortion slightly and giving +0.06 Speed Up and -0.3 Tears Down, This item was called Black Mushroom in Antibirth. the lost item pool, white, A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage, Each laser deals 3 damage per tick, up to 8 times for a total of 31.5 damage, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, horns, baby, with Lilith, After picking up 15 hearts, Isaac gains a permanent angelic familiar and a soul heart drops, Possible familiars include: Holy Water, Guardian Angel, Sworn Protector, The Relic and Seraphim, It is possible to get multiple followers by continuing to pick up hearts, at intervals of 15 hearts each, After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected, UNLOCK: Unlock this item by beating Boss Rush with Lilith, Two items now spawn in each of your item rooms, however only one can be taken and the other will disappear, A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts, While the effect is active, tears do double damage and have -0.30 Shot Speed, The crown will glow blue while active, if inactive it will appear grey, The effect will also deactivate for the rest of the current room when you take damage, regardless of your health, When a room clear would otherwise yield no rewards, it now spawns 1-3 pennies, REPENTANCE - Deep Pockets no longer adds a pill/card slot, instead increases money cap to 999, UNLOCK: Unlock this item by beating The Chest floor with Keeper, A flying familiar that bounces around the room with a damaging aura, dealing rapid damage to any enemies inside it and boosting Isaac's tear damage, While standing in the black aura, Isaac has a temporary 1.5x damage multiplier (this will stack if you have more than one Succubus), The aura deals 2.5 damage per tick or about 7.5 - 10 damage per second, UNLOCK: Unlock this item by beating The Lamb with Lilith, Gives you a different tear effect with every tear that you fire, Tear effects include: Anti-Gravity, Ball of Bandages (Lvl 4), Bumbo (Lvl 3), Continuum, Cupid's Arrow, Compound Fracture, Euthanasia, Explosivo, Eye of Greed, Fire Mind, Flat Stone, Flat Worm, God's Flesh, Godhead, Head of the Keeper, Holy Light, Hook Worm, Ipecac, Iron Bar, Jacob's Ladder, Knockout Drops, Lachryphagy, Little Horn, Lodestone, Mom's Contacts, Mom's Eyeshadow, Mom's Perfume, Mucormycosis, My Reflection, Mysterious Liquid, Ocular Rift, Ouija Board, Ouroboros Worm, The Parasite, Parasitoid, Polyphemus, Pop!, Proptosis, Pulse Worm, Ring Worm, Rotten Tomato, Rubber Cement, Serpent's Kiss, Sinus Infection, Spider Bite, Strange Attractor, Sulfuric Acid, Technology Zero, Tiny Planet, Trisagion and Wiggle Worm, With Dr. Fetus, this item will also cycle through random Bomb Modifiers (e.g. bad damage, bobs brain, When Isaac takes damage, a white attack fly will spawn that orbits him at a similar distance to the Distant Admiration fly, The fly orbits a lot faster than Distant Admiration or Forever Alone and deals 10 damage per tick, REPENTANCE - Best Bud's contact damage has been increased to 10 (from 5), * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Secret Rooms, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lazarus, Every time you take damage, you drop up to 2 different types of consumables on the ground, Dropped consumables can be any variant of its kind - e.g. pink, red, eye, glow moms contacts mom contact, Upon use, this item causes Isaac to fart and poison any enemies in close proximity, The Bean deals 5 damage, then poisons enemies for 6 total ticks of damage, The poison deals your current tear damage per tick, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, team bean, #teambean, brown, kidney, An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals, UNLOCK: Unlock this item by beating Satan with Maggy, * angel room pool, god room pool, angel room item, baby, wings, A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range, UNLOCK: Unlock this item by beating the Dark Room with Azazel, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, black, grey, No longer has an "on hit" effect, UNLOCK: Unlock this item by donating 999 pennies to the Shop, * shop room pool, shop item pool, stopwatch, blue, pocket, clock, Tears now revolve around Isaac's Body at a fixed distance until they hit the ground, Aiming in the opposite direction is often better due to how the tears circle around Isaac, Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets, REPENTANCE - Tiny Planet's orbit now more tightly follows Isaac. Pickups It is used in the phrase "fire and brimstone" to describe the torments of hell. Pressing it again allows you to throw it at enemies. It's possible to hold more than one trinket by taking Mom's Purse, Belly Button or using the Smelter to convert them into passive items. Each laser is emitted for about one second and hits twice, so it is possible to destroy some two-stage enemies in one shot (Globins and Hives along with the flies they spawn on death), or to strafe the shot over multiple enemies. Item Pool Each of them deal double your tear damage, similar to how standard blue flies work, War (Red) - Explodes when touching the enemy. Once you've beaten Mother once, a door will appear at the starting room in Depths II, which leads to the Mausoleum/Gehenna floors. Pressing the bomb button will put the next poop into the 'Hold' jar. It will also sometimes randomly drop bombs. Well Cain is supposed to be lucky right? Unlocked from Challenge #24 - PAY TO PLAY, Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect), Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. effect for the floor, UNLOCK: Unlock this item by beating Satan with Eden, Item Pool: Item Room, Library, Secret Room, * library pool, library room, book room pool, secret room pool, item room, treasure room, Tears can still hit Isaac if gravity applies for too long, Allows Isaac to squeeze between some objects, This item has a chance to spawn an additional curse room on each future floor, Causes a penny to spawn in all future Curse Rooms, Tears fired from your left eye gain roughly +28% fire rate increase, Causes your tears to be fired at staggered rates, Allows Angel Rooms to appears even if a Devil deal has been taken before, All shops now contain a trapdoor with a ladder, which leads down to a special shop. These ticks occur every 1/15th of a second (once every 4 frames). The first and second familiars spawn after 15 hits, then 30 hits for the third and fourth, Cambion Conception cannot grant more than 4 familiars in total, UNLOCK: Unlock this item by beating ??? Characters Quality The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. Chapters Sales can be randomly applied just like regular shops, The ladder disappears after leaving the starting room, even if you haven't used it yet, In Antibirth this was called Jacob's Ladder, which had to be renamed as Afterbirth+ already had an item with this name, UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau, Permanently shows the location of the boss room on the map, After defeating the shown boss fight, this item will activate a use of the Sun card (full heal and map reveal), fully recharge your active item, remove curses from the floor, gives +3 Damage Up and +1 Luck up for the rest of the floor, Only available inside a Planetarium - a room that has a base 1% chance to appear, which increases by +20% every time you skip an Item Room (Must not enter to count as skipped), In The Void floor it shows a random boss room, which isn't necessarily Delirium's room, Adds one extra secret room and one extra super secret room to each floor. It's the run that keeps on giving and continues to get stronger the farther you get. Isaac Hanson joined legislators and health officials . When you take damage and the cannon breaks, you take an additional 2 full hearts of damage and gain the Anemic effect for the room. Frozen enemies can be pushed into obstacles where they shatter on contact and fire ice shards around them. The priority list of what will drop from champion enemies in order is as follows: Soul Hearts - When you have no red heart containers and less than 2 soul hearts, Red Hearts (Full hearts) - While at 0.5 red hearts, Red Hearts (Full hearts) - When you have at least half a red heart container empty, Trinkets - If you have no trinkets and there are no trinkets on the ground in the room, Soul Hearts - When you have less than 6 total heart containers of any kind, If none of the above conditions are true, champions will resume dropping their regular pickups, UNLOCK: Unlock this item by defeating Greedier mode with Maggy, Allows you to fire tears diagonally by holding down two of the fire buttons at once, If you are using a gamepad, this item allows you to fire in any direction, The first enemy you kill in each new room will now explode and poison all nearby enemies, causing them to take periodic damage until they also die and explode, If you have lots of enemies near each other this can cause a chain reaction, killing lots of enemies in one go, Gives Isaac a finger which floats infront of him and points in the same direction he is facing or firing. These can be smaller or big batteries, Upon use, Mom's Bracelet allows you to grab objects in the room and throw them, damaging any enemies which are hit for 40 damage, Most objects can be thrown including pots, rocks, poops, tnt etc, Pressing the activate button again will drop the object where you stand, which doesn't consume a charge of use, Allows you to remove the skull on top of Host enemies, turning them into the red version, Counts as 1 of 3 mom items needed towards the Mom transformation, *, arm, moms, ring, bracers, zelda, gold band, golden band, power bracelet, When used, this item spawns a Peeper familiar for the current room, which deals 12 contact damage per tick to enemies and leaves red creep in its path, Using this item removes Isaac's right eye, causing tears from this eye to deal x1.5 your normal tear damage, Using it more than once in the same room will spawn multiple Peeper familiars, Fired tears now have a chance to summon a rift when they land on the ground, The spawned rift sucks in enemies, projectiles and pickups and deals damage to enemies caught inside for 2 seconds, The chance to fire the rift tear can improve based on your luck stat. Counts as 1 of 3 spider items needed towards the Spider Baby transformation. This allows you to choose between the item that originally spawned and a HP upgrade every time, This effect applies to most items, including those in the shop and devil room. A slow pulsing outline HUD effect appears for cards that would be buffed by Tarot Cloth, To see the full list of Tarot Card effects, check out the Mechanics > Tarot Cloth page, Every time you take damage, 10 high damage tears are fired in a circle around you (similar to the Tammy's Head effect), Tear damage is equal to Isaac's tear damage + 25 flat damage, Additionally, has a chance to activate the Anemic effect when taking damage for 2 seconds, Similar to Tammy's Head, this item synergizes with a lot of items (i.e. Treasure RoomTreasure Room This spawns friendly charger enemies and causes Isaac to deal 5 contact damage (same as the shade did). UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lilith, Item Pool: Item Room, Red Chest, Curse Room, During the transition between floors, this item shows you a preview of the item that will spawn in the item room, and the boss that will appear, This effect will work even if you have Curse of the Blind, but the item will still appear as a ? Endings. "I'm seeing red" Monsters Upon hitting the floor, an obstacle, or an enemy they burst into smaller tears in all directions. Isaac appears demonic with large curved horns and an angry expression. Endings. grey, gray, green, mouth, bobs rotten head, bob rotten head, Teleports Isaac to a random location on the map, Can't be used to teleport to the I AM ERROR room, REPENTANCE - Teleport! Endings. Similar to Explosive Diarrhea but with poop, Retro Vision - Pixelates the screen for a few seconds, obscuring your vision. One exception to this is if you are playing as Lazarus or have Lazarus' Rags - you will respawn in the same room and get the kill, Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear, UNLOCK: Unlock this item by defeating Greedier Mode with Lazarus, Item Pool: Shop, Devil Room, Curse Room, Red Chest, Demon Beggar, When used, the D1 duplicates 1 random pickup in the current room. ?, Satan and The Lamb as Tainted Blue Baby, Drops 2 bombs at once (only 1 bomb is removed from your total), UNLOCK: Unlock this trinket by defeating Mother as Tainted Blue Baby. Taking it will cause Mom's Shadow to spawn and chase you. Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. When an enemy takes damage from an enemy projectile, it will attempt to target the enemy that fired it, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Judas, Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room, Zodiac will give you a random zodiac item effect that changes after every floor, Possible item effects include: Taurus, Aries, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, Gemini or Pisces, UNLOCK: Unlock this item by beating Greed Mode with The Lost, Tears now have a random chance to apply a poison effect, dealing damage equal to your tears each tick, for 2 ticks, Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick), Enemies that were poisoned by contact damage have a 20% chance to drop a black sin heart when killed. This is decided by whatever you have the least of. Brimstone, probably one of the most iconic items in the franchise of The Binding of Isaac is also the item that got the most changes over the years and versi. This chance doesnt change if you take further damage, You effectively have a 4.4% chance for every minute that passes after taking damage to die, Self-inflicted damage i.e. ), Doesn't show the location of Secret or Super Secret rooms, Room icons will not show if a Curse of the Lost is in effect on the current floor, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, pink, red, Item Pool: Boss Room, Challenge Room, Beggar, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, brown, bowl, grey, gray, poop, fly, Item Pool: Boss Room, Beggar, Challenge Room, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, can, tin, brown, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, brown, sack, bag, fly, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, carton, fly, flies, milk, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, green, bone, lump, yellow. 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